- Nucleoside Reverse Transcriptase Inhibitors (NNRTI “nucs”):
This group of drugs prevents HIV reproduction by inhibiting the enzyme (reverse transcriptase) that the virus needs.
- Non-Nucleoside Reverse Transcriptase Inhibitors ( NNRTI “non-nuvcs”):
This group of drugs also blocks the reverse transcriptase.
- Protease Inhibitors:
This group inhibits the Protease, a substance HIV needs to reproduce.
- Entry Inhibitors (or fusion inhibitors):
This group interferes with binding, fusion and entry of HIV-1 to the host cell by blocking one of several targets. Maraviroc and enfuvirtide are the two currently available agents in this class.
- Integrase Inhibitors:
This group inhibits the enzyme integrase, which is responsible for integration of viral DNA into the DNA of the infected CD4 cell.
- Maturation Inhibitors:
This group inhibits the last step in gag processing in which the viral capsid polyprotein is cleaved, thereby blocking the conversion of the polyprotein into the mature capsid protein.
- CCR5 Receptor antagonists:
They bind to the CCR5 receptor on the surface of the Tcell and block HIV attachment to the cell.
Other drugs are also available that interfere with other steps in the process HIV uses to make copies of itself.
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